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www.data.gov.br – – Linde Brasil – Norma (Tecnologia de Computação e Informação), ISS – Relatório de Exclusão – Ipso Facto – Qualificações e Exclusão Category:Living people Category:1962 birthsInhibitory effect of the active component of Morus bombycifera on UVB-induced type I and type IV allergic reactions in rats. In this study, we investigated the inhibitory effect of the active component of Morus bombycifera on UVB (280-320 nm)-induced hypersensitivity in rats. The acetone extract of the leaves of Morus bombycifera was fractionated. The effect of the active fraction of Morus bombycifera on UVB-induced allergic reaction was examined using a croton oil-induced ear edema model and a dextran-induced paw edema model. Changes in mast cell degranulation, leukotriene B4 production, histamine release, and lymphocyte proliferation were evaluated in a rat peritoneal mast cell degranulation model. Additionally, the inhibitory effect of this active fraction of Morus bombycifera on the production of interleukin-4 and interferon-gamma in UVB-treated splenocytes was examined using a rat splenocyte culture system. The active fraction of Morus bombycifera significantly inhibited UVB-induced ear edema in rats, particularly in the early phase of ear edema. In addition, the level of histamine in UVB-exposed rat skin was reduced to the same extent as that in the control group. Furthermore, the same fraction inhibited mast cell degranulation and the production of leukotriene B4 in vitro. In addition, the active fraction of Morus bombycifera inhibited UVB-induced lymphocyte proliferation, and suppressed UVB-induced interleukin-4 and interferon-gamma production in splenocytes. These findings suggest that the active component of Morus bombycifera has an inhibitory effect on UVB-induced hypersensitivity. The inhibitory effect of Morus bombycifera on UVB-induced hypersensitivity may be mediated through the inhibition of mast cell degranulation and the modulation of Th

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